VENLAFAXINA 37.5 MG Капсулы твердые, пролонгированного действия

Содержание инструкции

1. VENLAFAXINA DOC Generici 37,5 mg prolonged-release hard capsules, 75 mg prolonged-release hard capsules, 150 mg prolonged-release hard capsules
   1. WHAT IS VENLAFAXINA DOC Generici AND WHAT IT IS USED FOR
   2. WHAT YOU NEED TO KNOW BEFORE YOU TAKE VENLAFAXINA DOC Generici
2. VENLAFAXINA DOC Generici is excreted in breast milk. There is a risk of an effect on the
   1. HOW TO TAKE VENLAFAXINA DOC Generici
   2. POSSIBLE SIDE EFFECTS
   3. HOW TO STORE VENLAFAXINA DOC Generici
   4. PACKAGE CONTENTS AND OTHER INFORMATION

VENLAFAXINA DOC Generici 37,5 mg prolonged-release hard capsules, 75 mg prolonged-release hard capsules, 150 mg prolonged-release hard capsules

Generic medicine

Read this leaflet carefully before you start taking this medicine as it contains important information for you.

• Keep this leaflet. You may need to read it again.
• If you have any questions, ask your doctor or pharmacist.
• This medicine has been prescribed for you only. Do not pass it on to others even if they have the same symptoms as you, as it may be harmful.
• If you get any side effects, even those not listed in this leaflet, tell your doctor or pharmacist. See section 4.

Contents of this leaflet:

• 1. What VENLAFAXINA DOC Generici is and what it is used for
• 2. What you need to know before you take VENLAFAXINA DOC Generici
• 3. How to take VENLAFAXINA DOC Generici
• 4. Possible side effects
• 5. How to store VENLAFAXINA DOC Generici
• 6. Contents of the pack and other information

1. WHAT IS VENLAFAXINA DOC Generici AND WHAT IT IS USED FOR

VENLAFAXINA DOC Generici is an antidepressant belonging to a group of medicines
called serotonin and noradrenaline reuptake inhibitors (SNRI). This group of
medicines is used for the treatment of depression and other conditions, such as anxiety
disorders. It is believed that people who are depressed and/or anxious have lower levels of
serotonin and noradrenaline in the brain. It is not fully understood how antidepressants
work, however they may help by raising the levels of serotonin and noradrenaline in the
brain.
VENLAFAXINA DOC Generici is a treatment for adults suffering from depression. It is also a
treatment for adults with the following anxiety disorders: generalized anxiety disorder, social
anxiety disorder (fear of or tendency to avoid social situations) and panic disorder (panic
attacks). Appropriate treatment of depression or anxiety disorder is important to help you
feel better. If left untreated, your condition may not resolve and may become more serious and more
difficult to treat.

2. WHAT YOU NEED TO KNOW BEFORE YOU TAKE VENLAFAXINA DOC Generici

Do not take VENLAFAXINA DOC Generici

• if you are allergic to venlafaxine or any of the other ingredients of this medicine (listed in section 6).
• if you are currently taking or have taken within the last 14 days any of the medicines known as irreversible monoamine oxidase inhibitors (MAOIs), used to treat depression or Parkinson's disease. Taking an irreversible MAOI together with VENLAFAXINA DOC Generici may cause serious or even life-threatening side effects. You must also wait at least 7 days after stopping treatment with VENLAFAXINA DOC Generici before taking any irreversible MAOI (see also sections “Serotonin Syndrome” and “Other medicines and VENLAFAXINA DOC Generici”)

Warnings and precautions
Medicines such as VENLAFAXINA DOC Generici (so-called selective serotonin reuptake inhibitors (SSRIs) and serotonin-noradrenaline reuptake inhibitors (SNRIs)) can cause symptoms of sexual dysfunction (see section 4). In some cases, these symptoms have been reported to persist after stopping treatment.
Talk to your doctor or pharmacist beforetaking VENLAFAXINA DOC Generici:

• If you are using other medicines that, when taken together with VENLAFAXINA DOC Generici, may increase the risk of developing serotonin syndrome (see section “Other medicines and VENLAFAXINA DOC Generici”).
• If you have eye problems, such as certain types of glaucoma (increased pressure inside the eye)
• If you have a history of high blood pressure
• If you have a history of heart problems
• If you have been told you have an irregular heartbeat.
• If you have a history of seizures
• If you have a history of low sodium levels in your blood (hyponatraemia)
• If you have a tendency to bruise easily or a tendency to bleed easily (history of bleeding disorders), or if you are using other medicines that may increase the risk of bleeding, e.g. warfarin (used to prevent blood clots).
• If you have a history of mania or bipolar disorder (feeling overexcited or euphoric)
• If you have a history of aggressive behaviour

VENLAFAXINA DOC Generici may cause a feeling of restlessness or inability to remain sitting or still during the very first weeks of treatment. If you experience these symptoms, you should report them to your doctor.
If you experience any of these conditions, talk to your doctor before using VENLAFAXINA DOC Generici.

Suicidal thoughts and worsening of your depression or anxiety disorder
If you are depressed and/or suffer from anxiety disorders, you may sometimes have thoughts of harming yourself or killing yourself. These may increase when you first start taking antidepressants, as it takes time for all medicines like these to start working, usually about two weeks but sometimes longer.
You are more likely to have these thoughts:

• If you have had previous thoughts of suicide or self-harm.
• If you are young. Information obtained from clinical studies has shown an increased risk of suicidal behaviour in young people (under 25 years of age) with psychiatric disorders, who were treated with an antidepressant.

If you have thoughts of harming yourself or committing suicide at any time, contact your doctor or go to the nearest hospital immediately.
It may help to tell a relative or close friend that you are depressed or suffering from thoughts that your depression or anxiety is getting worse, or if you are worried about changes in your behaviour.
Dry mouth
Dry mouth is reported in 10% of patients treated with venlafaxine. This may increase the risk of tooth decay (cavities). You should therefore pay particular attention to your oral hygiene.
Diabetes
Blood glucose levels may be altered due to VENLAFAXINA DOC Generici.
Therefore, it is possible that the dosages of medicines for diabetes may need to be adjusted.
Children and adolescents
VENLAFAXINA DOC Generici is generally not recommended for use in children and adolescents under the age of 18. Also, you should know that patients under 18 years of age have a greater risk of side effects, such as suicide attempts, suicidal thoughts and hostility (mainly aggression, oppositional behaviour and anger) when taking this class of medicines. Despite this, the doctor may prescribe VENLAFAXINA DOC Generici to patients under the age of 18 because they believe it is in their best interest.
If the doctor has prescribed this medicine for a patient under 18 years of age, and you want to discuss it, talk to the doctor. You should inform the doctor if any of the symptoms listed occur or worsen when a patient under 18 years of age is taking VENLAFAXINA DOC Generici. Furthermore, the long-term effects of VENLAFAXINA DOC Generici on growth, maturation and cognitive and behavioural development in this age group have not been demonstrated.

Other medicines and VENLAFAXINA DOC Generici
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
The doctor will decide whether you can use VENLAFAXINA DOC Generici with other medicines.
Do not start or stop taking any other medicines, including over-the-counter medicines, herbal remedies, before asking your doctor or pharmacist.

• Monoamine oxidase inhibitors used to treat depression or Parkinson's disease must notbe taken with VENLAFAXINA DOC Generici. Tell your doctor if you have taken these medicines in the last 14 days (MAOIs: see section “What you need to know before you take VENLAFAXINA DOC Generici”)
• Serotonin Syndrome:a potentially life-threatening condition, Neuroleptic Malignant Syndrome (NMS), can occur with treatment with venlafaxine, especially when taken with other medicines. Examples of these medicines include:
• triptans (used for migraine)
• medicines for the treatment of depression, for example SNRIs, SSRIs, tricyclics, or medicines containing lithium
• medicines containing amphetamines (used to treat attention deficit/hyperactivity disorder (ADHD), narcolepsy and obesity)
• medicines containing linezolid, an antibiotic (used to treat infections)
• medicines containing moclobemide, an MAOI (used to treat depression)
• medicines containing sibutramine (used for weight loss)
• medicines containing tramadol, fentanyl, tapentadol, pethidine, or pentazocine (used to treat severe pain)
• medicines containing dextromethorphan (used to treat cough)
• medicines containing methadone (used to treat opioid dependence or acute pain)
• medicines that contain methylene blue (used to treat high levels of methaemoglobin in the blood)
• St John's Wort preparations (also called Hypericum Perforatum, a herbal remedy used to treat mild depression)
• products containing tryptophan (used for sleep disorders and depression)
• antipsychotics (used to treat disorders whose symptoms are hearing, seeing or experiencing things that do not exist, false beliefs, unjustified suspicion, confused reasoning and social withdrawal).

Signs and symptoms of serotonin syndrome may include a combination of:
restlessness, hallucinations, loss of coordination, rapid heartbeat, increased body temperature, rapid fluctuations in blood pressure, hyperactive reflexes, diarrhoea, coma, nausea, vomiting.
In its most severe form, serotonin syndrome can resemble Neuroleptic Malignant Syndrome (NMS). Signs and symptoms of NMS may include a combination of fever, rapid breathing, sweating, severe muscle rigidity, confusion and increased muscle enzymes (determined by blood tests).

Immediately inform your doctor or go to the nearest Emergency Room if you think you have serotonin syndrome.
Talk to your doctor if you are taking medicines that may affect your heart rate.
Examples of these medicines include:

• antiarrhythmics such as quinidine, amiodarone, sotalol or dofetilide (used to treat irregular heartbeat)
• antipsychotics such as thioridazine (see also serotonin syndrome above)
• antibiotics such as erythromycin or moxifloxacin (used to treat bacterial infections) antihistamines (used to treat allergies) Also, the following medicines may interfere with VENLAFAXINA DOC Generici and must be used with caution. It is particularly important that you tell your doctor or pharmacist if you are using medicines that contain:
• ketoconazole (an antifungal medicine)
• haloperidol or risperidone (for the treatment of psychiatric disorders)
• metoprolol (a beta-blocker for the treatment of high blood pressure and heart problems)

VENLAFAXINA DOC Generici with food, drinks and alcohol
You should take VENLAFAXINA DOC Generici with food (see section “How to take VENLAFAXINA DOC Generici”).
You should not drink alcohol while taking VENLAFAXINA DOC Generici.

Pregnancy and breastfeeding
If you are pregnant, suspect you may be pregnant or are planning to become pregnant, ask your doctor or pharmacist for advice before taking this medicine. You should only take VENLAFAXINA DOC Generici after discussing the potential benefits and risks to the fetus with your doctor.
Make sure your midwife and/or your doctor are informed that you are being treated with VENLAFAXINA DOC Generici.
Medicines similar to this medicine (SSRIs), if taken during pregnancy, may increase the risk of a serious paediatric condition called persistent pulmonary hypertension of the newborn (PPHN) which causes rapid breathing in the newborn and a bluish skin colour. These symptoms usually appear within the first 24 hours of birth. Immediately inform your midwife and/or your doctor if your baby should present these symptoms.
If you are taking this medicine during pregnancy, your baby may present other symptoms in addition to breathing problems if not adequately fed at birth. If your baby presents these symptoms at birth and you are worried, ask for advice from your doctor and/or midwife.

VENLAFAXINA DOC Generici is excreted in breast milk. There is a risk of an effect on the

child. Therefore, you should discuss this with your doctor, who will decide whether to discontinue
breastfeeding or therapy with this medicine.

Driving and operating machinery
Do not drive and do not use tools or machinery until you understand what effects VENLAFAXINA DOC
Generici has on you.

3. HOW TO TAKE VENLAFAXINA DOC Generici

Take this medicine following exactly the instructions of your doctor. If you have doubts
consult your doctor or pharmacist.
The recommended starting dose for the treatment of depression, generalized anxiety disorder
and social anxiety disorder is 75 mg per day.
The doctor may gradually increase the dose and, if necessary, up to a maximum dose of
375 mg per day for depression.
If you are being treated for panic disorder, the doctor will start with a low dose (37.5 mg) and
then gradually increase the dose.
The maximum dose for generalized anxiety disorder, social anxiety disorder and panic disorder is
225 mg per day.
Take VENLAFAXINA DOC Generici at about the same time each day, in the morning and evening. The
capsules must be swallowed whole with a liquid and must not be opened, broken, chewed or
dissolved.
You must take VENLAFAXINA DOC Generici with food.
If you have liver or kidney problems, talk to your doctor, as a dose adjustment of VENLAFAXINA DOC
Generici may be necessary.
Do not stop treatment with this medicine without consulting your doctor (see the
paragraph “If you stop taking VENLAFAXINA DOC Generici”).

If you take more VENLAFAXINA DOC Generici than you should
Contact your doctor or pharmacist immediately if you take more of VENLAFAXINA
DOC Generici than prescribed by your doctor.
Symptoms of a possible overdose may include rapid heartbeat, changes
in consciousness (ranging from drowsiness to coma), blurred vision, seizures, and
vomiting.

If you forget to take VENLAFAXINA DOC Generici
If you forget to take a dose, take it as soon as you remember. However, if you are due to take the
next dose when you remember the forgotten dose, skip the forgotten dose and take only one
dose as usual. Do not take a double dose to make up for a forgotten dose. Do not take more than the
daily amount of VENLAFAXINA DOC Generici
that has been prescribed to you in one day.

If you stop taking VENLAFAXINA DOC Generici
Do not stop treatment or reduce the dose without your doctor's advice, even if you feel better.
If your doctor believes you no longer need VENLAFAXINA DOC Generici, they may ask you to
gradually reduce the dose before stopping treatment completely. It is known that undesirable effects occur when patients stop treatment with VENLAFAXINA
DOC Generici, especially when VENLAFAXINA DOC Generici is stopped abruptly or
when the dose is reduced too quickly. Some patients may experience symptoms such as
fatigue, dizziness, lightheadedness, headache, insomnia, nightmares, dry
mouth, loss of appetite, nausea, diarrhea, nervousness, agitation, confusion, tinnitus (ringing
in the ears), tingling or rarely sensations of electric shock, weakness, sweating,
seizures or flu-like symptoms.
Your doctor will explain how to gradually stop treatment with VENLAFAXINA
DOC Generici. If you experience any of these or other symptoms that bother you, contact
your doctor for further advice.
If you have any questions about the use of this medicine, ask your doctor or pharmacist.

4. POSSIBLE SIDE EFFECTS

Like all medicines, this medicine can cause side effects, although not everyone will experience them.
If you experience any of the following effects, do not take any more VENLAFAXINA DOC
Generici. Seek immediate medical attention, or go to the nearest hospital emergency room.
Uncommon (may affect up to 1 in 100 people)

• Swelling of the face, mouth, tongue, throat, hands, feet and/or itchy rash (urticaria), difficulty swallowing and breathing

Rare (may affect up to 1 in 1000 people)

• Chest tightness, wheezing, difficulty swallowing or breathing
• Severe skin rash, itching or urticaria (raised, red or pale patches of skin that often itch)
• Signs and symptoms of serotonin syndrome, which may include restlessness, hallucinations, loss of coordination, rapid heartbeat, increased body temperature, rapid fluctuations in blood pressure, hyperactive reflexes, diarrhea, coma, nausea, vomiting
• In its most severe form, serotonin syndrome can resemble Neuroleptic Malignant Syndrome (NMS). Signs and symptoms of NMS may include a combination of fever, rapid breathing, sweating, severe muscle rigidity, confusion, and increased muscle enzymes (determined by blood tests).
• Signs of infection, such as high fever, chills, tremors, headache, sweating, flu-like symptoms. This may be caused by blood disorders leading to an increased risk of infection.
• Skin rash, which may involve severe blistering and peeling of the skin
• Unexplained muscle pain, tenderness, or weakness. These may be signs of rhabdomyolysis.

Other side effects about which you should immediately inform your doctorare (the frequency of
these adverse effects is reported below in the list “other side effects that may occur”):

• Cough, wheezing, shortness of breath that may be accompanied by high temperature.
• Black tarry stools or blood in the stools.
• Itching, yellowing of the skin or eyes, or dark urine, which may be symptoms of liver inflammation (hepatitis).
• Heart problems such as rapid or irregular heartbeat, increased blood pressure
• Heart problems, such as fast or irregular heartbeat, increased blood pressure.
• Eye problems, such as blurred vision, dilated pupils
• Nervous system problems, such as dizziness, tingling, movement disorders (spasms or muscle stiffness, convulsions).
• Psychiatric problems, such as hyperactivity and unusual feeling of overexcitement
• Withdrawal syndrome (see paragraph “How to take VENLAFAXINA DOC Generici; If you stop taking VENLAFAXINA DOC Generici”).
• Prolonged bleeding - if you cut or injure yourself, it may take longer than usual for the bleeding to stop.

Do not be concerned if you notice small granules or white pellets in your stool after taking this medicine.
Inside the VENLAFAXINA DOC Generici capsules are spheroids (small white pellets) that contain the active ingredient (venlafaxine). These spheroids are
released from the capsule in your stomach. Traveling along the
gastrointestinal tract, they slowly release the venlafaxine. The “shell” of the spheroids does not dissolve and
is eliminated in the stool. Therefore, even if you see spheroids in your stool, the dose of the
medicine has been absorbed.

Other side effects that may occur
Very common (may affect more than 1 in 10 people)

• Dizziness, headache, drowsiness, Insomnia
• Nausea, dry mouth, constipation
• Sweating (including night sweats)

Common (may affect up to 1 in 10 people)

• Decreased appetite
• Confusion, dizziness, feeling of detachment from oneself; anorgasmia, decreased libido; agitation, nervousness;; abnormal dreams
• Tremor, feeling of restlessness or inability to sit still or remain quiet; tingling, altered taste sensation, increased muscle tone
• Visual disturbances including blurred vision, dilated pupils, inability of the eyes to focus automatically from near to far
• Ringing in the ears (tinnitus)
• Rapid heartbeat, palpitations
• Increased blood pressure, hot flashes
• Shortness of breath, yawning
• Vomiting, diarrhea
• Mild skin rash, itching
• Increased frequency of urination, inability to urinate, difficulty emitting urine
• Menstrual irregularities such as increased bleeding or increased irregularity of bleeding, abnormal ejaculation/orgasm (males); erectile dysfunction (impotence)
• Weakness (asthenia); fatigue, chills
• Weight gain, weight loss
• Increased cholesterol

Uncommon (may affect up to 1 in 100 people)

• Hyperactivity, racing thoughts and decreased need for sleep (mania)
• Hallucinations, feeling of detachment from reality, abnormal orgasm, absence of sensations or emotions, feeling of overexcitement, bruxism (teeth grinding)
• Fainting, involuntary muscle movements, impaired coordination and balance, Feeling of dizziness (especially when getting up too quickly), decreased blood pressure
• Vomiting blood, black tarry stools or blood in the stools, which may be a sign of internal bleeding
• Sensitivity to sunlight, bruising, abnormal hair loss
• Urinary incontinence
• Rigidity, spasms and involuntary movements of the muscles
• Mild changes in blood levels of liver enzymes

Rare (may affect up to 1 in 1000 people)

• Convulsions
• Cough, shortness of breath and wheezing that may be accompanied by high temperature
• Disorientation and confusion often accompanied by hallucinations (delirium)
• Excessive intake of water (known as SIADH)
• Decreased blood levels of sodium
• Severe eye pain and decreased or blurred vision
• Abnormal heartbeat, fast or irregular, which may lead to fainting
• Severe abdominal or back pain (which may indicate a serious problem with the intestines, liver or pancreas)
• Itching, yellowing of the skin or eyes, dark urine, or flu-like symptoms, which are signs of liver inflammation (hepatitis)

Very rare (may affect up to 1 in 10,000 people)

• Prolonged bleeding, which may be a sign of reduced number of platelets in the blood leading to an increased risk of bruising or bleeding
• Abnormal production of breast milk
• Unexpected bleeding e.g. bleeding gums, blood in the urine or vomit, or the sudden appearance of bruises or broken blood vessels (burst veins)

Frequency not known (cannot be estimated from available data)

• Suicidal ideation and behaviour, cases of suicidal ideation and behaviour have been reported during therapy with venlafaxine or immediately after discontinuation of treatment (see paragraph 2 WHAT YOU NEED TO KNOW BEFORE YOU TAKE VENLAFAXINA DOC Generici)
• Aggression
• Vertigo

Sometimes VENLAFAXINA DOC Generici causes side effects of which you may not
be aware, such as increases in blood pressure or abnormal heartbeat; mild changes
in blood levels of liver enzymes, sodium or cholesterol. More rarely, VENLAFAXINA DOC
Generici can reduce the functionality of the platelets in your blood, resulting in an increased
risk of bruising and bleeding. Therefore, your doctor may want to do blood tests
occasionally, especially if you are taking VENLAFAXINA DOC Generici for a long time.

Reporting of side effects
If you get any side effects, even those not listed in this leaflet, tell your doctor or pharmacist. You can also report side effects directly
through the national reporting system at
https://www.aifa.gov.it/content/segnalazioni-reazioni-avverse.
By reporting side effects you can help provide more information on the
safety of this medicine.

5. HOW TO STORE VENLAFAXINA DOC Generici

Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the packaging. The expiry date refers to the last day of that month.
Do not store at a temperature above 30ºC .
Do not dispose of any medicine in wastewater or household waste. Ask your pharmacist how to
dispose of medicines you no longer use. This will help protect the environment.

6. PACKAGE CONTENTS AND OTHER INFORMATION

What VENLAFAXINA DOC Generici contains
The active ingredient is venlafaxine. Each prolonged-release hard capsule contains 37.5 mg, 75
mg or 150 mg of venlafaxine as venlafaxine hydrochloride.
The other ingredients are:

• 37.5 mg prolonged-release hard capsules: Capsule content:hypromellose, ammonium methacrylate copolymer (type B), sodium lauryl sulfate, magnesium stearate; Coating:basic butyl methacrylate copolymer 12.5%; Capsule:gelatin, titanium dioxide (E 171); Ink:shellac, black iron oxide (E 172), Propylene glycol (E1520).

75 mg prolonged-release hard capsules:

Capsule content:hypromellose, ammonium methacrylate copolymer (type B), sodium
lauryl sulfate, magnesium stearate; Coating:basic butyl methacrylate copolymer 12.5%;

Capsule:gelatin, titanium dioxide (E 171), red iron oxide (E 171); Ink:shellac,
black iron oxide (E 172), Propylene glycol (E 1520).
150 mg prolonged-release hard capsules:

Capsule content:hypromellose, ammonium methacrylate copolymer (type B), sodium
lauryl sulfate, magnesium stearate; Coating:basic butyl methacrylate copolymer 12.5%;

Capsule:gelatin, titanium dioxide (E 171), erythrosine (E127), indigotine I (E 132); Ink:
shellac, black iron oxide (E 172); Propylene glycol (E 1520).

Description of the appearance of VENLAFAXINA DOC Generici and package contents
37.5 mg prolonged-release hard capsules: opaque white color – hard gelatin capsules (type 0)
of opaque white color containing a round, biconvex, film-coated tablet, with the
inscription VENimprinted on the cap and 37.5on the body.
75 mg prolonged-release hard capsules: opaque peach color – hard gelatin capsules (type 0) of
opaque peach color containing two round, biconvex, film-coated tablets, with the inscription

VENimprinted on the cap and 75on the body.
150 mg prolonged-release hard capsules: opaque red color – hard gelatin capsules (type

• 00) of opaque red color containing three round, biconvex, film-coated tablets, with the inscription VENimprinted on the cap and 150on the body.

• 37.5 mg: 10, 20, 28, 30, 98 and 100 capsules 75 mg: 14, 28, 30, 56, 98 and 100 capsules 150 mg: 10, 28, 30, 56, 98 and 100 capsules

Not all pack sizes may be marketed.

Marketing Authorisation Holder
DOC Generici S.r.l.
Via Turati, 40
20121 Milan

Manufacturers
Pharmathen S.A.
6 Dervenakion str.,
153 51 Pallini, Attiki
Greece
Pharmathen International S.A.
Sapes Industrial Park
Block 5
69300 Rodopi
Greece
Apotex Nederland B.V.
Bio Science Park
Archimedesweg 2
2333 CN Leiden
Netherlands
LAMP S. Prospero SPA
Via della Pace 25A
41030 S. Prospero S/S (MO)
Italy

This medicinal product is authorised in the Member States of the European Economic Area with the
following denominations:
BE: Venlafaxine Apotex 37.5 mg, 75 mg, 150 mg hard capsules with prolonged release, hard
CZ: APO-VENLAFAXIN PROLONG 75 mg, 150 mg Prolonged Release Capsule
NL: Venlafaxine Apotex XR 37.5 mg, 75 mg, 150 mg Katwijk retard, hard capsules with prolonged
release, hard
PL: Lafactin 37.5 mg, 75 mg, 150 mg Prolonged-Release Capsules
UK: Venaxx XL 75 mg, 150 mg prolonged-release capsules