CONNETTIVINA 0.2% + 1% Крем

Содержание инструкции

1. Connettivina Plus 2 mg + 40 mg impregnated gauzes, 4 mg + 80 mg impregnated gauzes, 12 mg + 240 mg impregnated gauzes
   1. What is Connettivina Plus and what is it used for
   2. What you need to know before using Connettivina Plus
   3. How to use Connettivina Plus
   4. Possible side effects
   5. How to store Connettivina Plus
   6. Package Contents and Other Information
2. Connettivina Plus 2 mg/g + 10 mg/g cream
   1. What is Connettivina Plus and what is it used for
   2. What you need to know before using Connettivina Plus
   3. How to use Connettivina Plus
   4. Possible side effects
   5. How to store Connettivina Plus
   6. Contents of the pack and other information

Connettivina Plus 2 mg + 40 mg impregnated gauzes, 4 mg + 80 mg impregnated gauzes, 12 mg + 240 mg impregnated gauzes

Sodium hyaluronate + silver sulfadiazine

Read this leaflet carefully before using this medicine as it contains important
information for you.
Always use this medicine exactly as described in this leaflet or as your doctor or pharmacist has told you.

• Keep this leaflet. You may need to read it again.
• If you want more information or advice, ask your pharmacist.
• If any side effects occur, including those not listed in this leaflet, tell your doctor or pharmacist. See section 4.
• See a doctor if you do not feel better or if your symptoms worsen after a short period of treatment.

Contents of this leaflet:

• 1. What Connettivina Plus is and what it is used for
• 2. What you need to know before you use Connettivina Plus
• 3. How to use Connettivina Plus
• 4. Possible side effects
• 5. How to store Connettivina Plus
• 6. Contents of the pack and other information

1. What is Connettivina Plus and what is it used for

Connettivina Plus impregnated gauze contains two active ingredients: sodium hyaluronate and silver sulfadiazine and belongs to a class of medicines defined as healing and disinfectant.
Hyaluronic acid is a substance naturally produced by our body. Local supply of hyaluronic acid facilitates the wound healing process.
Silver sulfadiazine is an active ingredient belonging to the family of sulfonamide antibiotics, it is able to block bacterial replication mechanisms and thus counteract the formation of infections.
Connettivina Plus impregnated gauze is indicated for the local treatment of wounds at an early stage (before the skin tears) and for the treatment of mild degree burns (I and II degree burns).

2. What you need to know before using Connettivina Plus

Do not use Connettivina Plus:
if you are allergic to the active ingredient or any of the other ingredients of this medicine (listed in
section 6).

Warnings and precautions
Consult your doctor or pharmacist before using Connettivina Plus if:
you have had a hypersensitivity reaction (allergic reaction) after taking sulfonamides;
you have severe liver problems (hepatic insufficiency);
you have severe kidney problems (renal insufficiency);
if you are pregnant or breastfeeding.

Other medicines and Connettivina Plus
Tell your doctor or pharmacist if you are taking, have recently taken, or might take any
other medicines.
Take particular care when using Connettivina Plus together with proteolytic enzymes for local use,
as their action may be prevented by the components present in the gauze.
Do not use simultaneously with disinfectants containing quaternary ammonium salts.

Pregnancy and breastfeeding
If you are pregnant, suspect you are pregnant, are planning a pregnancy, or are breastfeeding, ask your doctor
or pharmacist for advice before using this medicine.
Connettivina Plus should not be used during pregnancy or breastfeeding unless your doctor considers that the
therapeutic benefits outweigh the possible risks. In such cases, Connettivina Plus must be used
only under the direct supervision of your doctor.

Driving and operating machinery
Connettivina Plus does not impair the ability to drive vehicles or operate machinery.
Connettivina Plus impregnated gauze contains polyethylene glycol 4000. It may cause skin irritation.

3. How to use Connettivina Plus

Use this medicine following exactly as described in this leaflet or as instructed by your doctor or pharmacist. If you have any doubts, consult your doctor or pharmacist.
Apply one or more Connettivina Plus dressings, depending on the extent of the lesion to be treated, two or more times a day.
Before applying CONNETTIVINA PLUS, the affected areas should be cleaned, preferably with sterile saline solution (NaCl 0.9%) and disinfected using antiseptics preferably containing iodopovidone or chlorhexidine. If your doctor deems it necessary, surgical cleaning should be performed.
In the treatment of burns, cleaning the lesions is preferably done with water alone or sterile saline solution, avoiding disinfection with antiseptic agents before applying Connettivina PLUS.
Do not interrupt treatment until the lesion is completely healed.
Consult your doctor if symptoms persist after a short period of treatment, or at any time if they worsen.

If you use more Connettivina Plus than you should
In case of accidental use of an excessive dose of Connettivina Plus, immediately inform your doctor or go to the nearest hospital.
No cases of overdose due to the use of an excessive amount of Connettivina Plus are known.

If you forget to use Connettivina Plus
If you forgot to apply the dressing, do so as soon as you remember. Then continue application according to the usual schedule.

If you stop using Connettivina Plus
If you have any doubts about the use of this medicine, consult your doctor or pharmacist.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.
After application of CONNETTIVINA PLUS gauze, local reactions (pain, burning,
itching) may occur, even of an allergic nature.
Following the application of Connettivina Plus to extensive areas of the skin, you may experience
the side effects that are usually observed with the intake of medicines based on sulfonamides (a class
of drugs to which sulfadiazine belongs) orally or by injection (systemic routes) such as:

• serious kidney problems (renal failure);
• inflammation of the liver as a reaction to certain substances to which you are exposed (toxic hepatitis);
• reduction in the number of white blood cells (agranulocytosis and leukopenia) and platelets (thrombocytopenia) circulating in the blood.

Reporting of side effects
If you experience any side effects, including those not listed in this leaflet, please inform your
doctor or pharmacist. You can also report side effects directly through the national reporting system at: http://www.agenziafarmaco.it/it/responsabili .
By reporting side effects you can help provide more information on the safety of
this medicine.

5. How to store Connettivina Plus

Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the packaging after “Exp”. The expiry date refers to the last day of that month.
The expiry date indicated refers to the medicine in intact packaging, correctly stored.
Store at a temperature below 30°C.
Do not dispose of any medicine in wastewater or household waste. Ask your pharmacist how to dispose of
medicines that you no longer use. This will help protect the environment.

6. Package Contents and Other Information

What Connettivina Plus Contains

Connettivina Plus 2 mg + 40 mg impregnated dressings
The active ingredients are sodium hyaluronate and silver sulfadiazine.
Each dressing is impregnated with 4 g of cream containing 2 mg of hyaluronic acid and 40 mg of silver
sulfadiazine.
The other components are: polyethylene glycol 4000, glycerol, purified water.

Connettivina Plus 4 mg + 80 mg impregnated dressings
The active ingredients are sodium hyaluronate and silver sulfadiazine.
Each dressing is soaked with 8 g of cream containing 4 mg of hyaluronic acid and 80 mg of silver
sulfadiazine.
The other components are: polyethylene glycol 4000, glycerol, purified water.

Connettivina Plus 12 mg + 240 mg impregnated dressings
The active ingredients are sodium hyaluronate and silver sulfadiazine.
Each dressing is soaked with 24 g of cream containing 12 mg of hyaluronic acid and 240 mg of
silver sulfadiazine.
The other components are: polyethylene glycol 4000, glycerol, purified water.

Description of the Appearance of Connettivina Plus and Package Contents

Connettivina Plus 2 mg + 40 mg impregnated dressings
One package contains 10 impregnated dressings of 10x10 cm, contained in a single sealed pouch of paper-
aluminum-polyethylene.

Connettivina Plus 4 mg + 80 mg impregnated dressings
One package contains 10 impregnated dressings of 10x20 cm, contained in a single sealed pouch of paper-
aluminum-polyethylene.

Connettivina Plus 12 mg + 240 mg impregnated dressings
One package contains 5 impregnated dressings of 20x30 cm, contained in a single sealed pouch of paper-
aluminum-polyethylene.

Marketing Authorisation Holder and Manufacturer

Marketing Authorisation Holder
Fidia Farmaceutici S.p.A.
Via Ponte della Fabbrica, 3/A
35031 Abano Terme (PD)

Manufacturer
Fidia Farmaceutici S.p.A.
Via Ponte della Fabbrica, 3/A
35031 Abano Terme (PD)

Connettivina Plus 2 mg/g + 10 mg/g cream

Sodium hyaluronate + silver sulfadiazine

Read this leaflet carefully before using this medicine as it contains important information for you.
Always use this medicine exactly as described in this leaflet or as your doctor or pharmacist has told you to do.

• Keep this leaflet. You may need to read it again.
• If you want more information or advice, ask your pharmacist.
• If any side effects occur, including those not listed in this leaflet, tell your doctor or pharmacist. See section 4.
• See a doctor if you do not feel better or if your symptoms worsen after a short period of treatment.

Contents of this leaflet:

• 1. What Connettivina Plus is and what it is used for
• 2. What you need to know before using Connettivina Plus
• 3. How to use Connettivina Plus
• 4. Possible side effects
• 5. How to store Connettivina Plus
• 6. Contents of the pack and other information

1. What is Connettivina Plus and what is it used for

Connettivina Plus 2 mg/g + 10 mg/g cream contains two active ingredients: sodium hyaluronate and
silver sulfadiazine, and belongs to a class of medicines defined as wound healing and disinfectant agents.
Hyaluronic acid is a substance naturally produced by our body. The local supply of hyaluronic
acid facilitates the process of wound healing.
Silver sulfadiazine is an active ingredient belonging to the family of sulfonamide antibiotics, it is
able to block the replication mechanisms and thus counteract the formation of infections.
Connettivina Plus 2 mg/g + 10 mg/g cream is indicated for the local treatment of sores at an early stage
(before the skin tears) and for the treatment of mild degree burns (first and second degree burns).

2. What you need to know before using Connettivina Plus

Do not use Connettivina Plus:

• if you are allergic to the active ingredient or to any of the other ingredients of this medicine (listed in section 6).

Warnings and precautions
Consult your doctor or pharmacist before using Connettivina Plus if:
you have had a hypersensitivity reaction (allergic reaction) after taking sulfonamides;
you have severe liver problems (hepatic insufficiency);
you have severe kidney problems (renal insufficiency);
if you are pregnant or breastfeeding.

Other medicines and Connettivina Plus
Tell your doctor or pharmacist if you are taking, have recently taken or might take any
other medicine.
Take particular care when using Connettivina Plus together with proteolytic enzymes for local use,
as their action may be prevented by the components present in the cream.
Do not use simultaneously with disinfectants containing quaternary ammonium salts.

Pregnancy and breastfeeding
If you are pregnant, suspect you are pregnant, are planning a pregnancy, or are breastfeeding,
ask your doctor or pharmacist for advice before using this medicine.
Connettivina Plus should not be used during pregnancy or breastfeeding unless your doctor
considers that the therapeutic benefits outweigh the possible risks. In such cases, Connettivina Plus must be used
only under the direct supervision of your doctor.

Driving and operating machinery
Connettivina Plus does not impair the ability to drive vehicles or operate machinery.

Connettivina Plus cream contains polyethylene glycol 400 monostearate.It may cause skin irritation.

4. How to use Connettivina Plus

Use this medicine following exactly the instructions in this leaflet or as indicated by your doctor or pharmacist. If you have any doubts, consult your doctor or pharmacist.
Apply a uniform layer of cream with a thickness of 2-3 mm to the lesion, 1 or 2 times a day.
Before applying CONNETTIVINA PLUS, the affected areas should be cleaned, preferably with
sterile saline solution (NaCl 0.9%) and disinfected with antiseptics preferably containing
iodopovidone or chlorhexidine. If your doctor deems it necessary, surgical cleaning should be performed.
In the treatment of burns, cleaning the lesions is preferably done with water alone or sterile saline solution, avoiding disinfection with antiseptic agents before applying Connettivina
PLUS.
Do not interrupt treatment until the lesion is completely healed.
Consult your doctor if symptoms persist after a short period of treatment, or at any time, if
they worsen.

If you use more Connettivina Plus than you should
In case of accidental use of an excessive dose of Connettivina Plus, immediately inform your doctor
or go to the nearest hospital.
No cases of overdose due to the use of an excessive amount of Connettivina Plus are known.

If you forget to use Connettivina Plus
If you forgot to apply the cream, do so as soon as you remember. Then continue application
according to the usual schedule.

If you stop using Connettivina Plus
If you have any doubts about the use of this medicine, consult your doctor or pharmacist.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.
After application of CONNETTIVINA PLUS, local reactions (pain, burning,
itching) may occur, even of an allergic nature.
Following the application of Connettivina Plus to extensive areas of the skin, you may experience the
side effects that are usually observed with the intake of medicines based on sulfonamides (a class
of drugs to which sulfadiazine belongs) orally or by injection (systemic routes) such as:

• serious kidney problems (renal failure);
• inflammation of the liver as a reaction to certain substances to which you are exposed (toxic hepatitis);
• reduction in the number of white blood cells (agranulocytosis and leukopenia) and platelets (thrombocytopenia) circulating in the blood. Reporting of side effectsIf you experience any side effect, including those not listed in this leaflet, please inform your doctor or pharmacist. You can also report side effects directly through the national reporting system at: http://www.agenziafarmaco.it/it/responsabili . By reporting side effects you can help provide more information on the safety of this medicine.

5. How to store Connettivina Plus

Keep this medicine out of sight and reach of children.
Do not use this medicine after the expiry date which is stated on the packaging after “Scad”. The expiry date refers to the last day of that month.
The expiry date indicated refers to the medicine in intact packaging, correctly stored.
Store at a temperature below 30°C.
Do not dispose of any medicine in wastewater or household waste. Ask your pharmacist how to dispose of
medicines you no longer use. This will help protect the environment.

7. Contents of the pack and other information

What Connettivina Plus contains
The active ingredients are: sodium hyaluronate and silver sulfadiazine.
1 g of cream contains 2 mg of sodium hyaluronate and 10 mg of silver sulfadiazine.
The other ingredients are: polyethylene glycol 400 monostearate, decyl oleate, emulsifying wax
glycerol, sorbitol solution 70%, purified water.

Description of the appearance of Connettivina Plus and contents of the pack
Connettivina Plus 2 mg/g + 10 mg/g is a cream contained in an aluminium tube of 25 g.

Marketing Authorisation Holder and manufacturer

Marketing Authorisation Holder
Fidia Farmaceutici S.p.A.
Via Ponte della Fabbrica, 3/A
35031 Abano Terme (PD)

Manufacturers
Fidia Farmaceutici S.p.A.
Via Ponte della Fabbrica, 3/A
35031 Abano Terme (PD)
Zeta Farmaceutici S.p.A.
Via Galvani, 10
36066 Sandrigo (VI)